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Improving detection of Breast Cancer with compression at optimal pressure
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Personalized breast compression without unnecessary discomfort.
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Reproducible mammogram while avoiding
extreme pressures.
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Clear visual guideline for
every breast compression.
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Highly reproducible breast compression, year after year.
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Patented technology that optimizes breast compression
to what is strictly necessary.

We are inspired to improve mammography


Worldwide, circa 150 million mammographic examinations are performed every year. To get the best image quality with the least amount of radiation, the breast needs to be compressed.

We developed a patented technology for a highly reproducible procedure without unnecessary discomfort. An optimized breast examination contributes to the early detection of cancer which ultimately can saves lives.

Latest news, publications and more related articles


Press release - Groundbreaking pressure based mammographic paddle at European Radiology Congress (ECR), Vienna - 01-03-2017

Sigmascreening to demonstrate its groundbreaking pressure based mammographic paddle at European Radiology Congress (ECR), Vienna

• ECR 1-5 March – EXPO Hall X1 – Booth no. 22
• Science shows that optimally controlled mammographic pressure may lead to the detection of more tumors and earlier oncology intervention
• The Sensitive Sigma™ paddle generates reproducible mammograms for women during screening, while avoiding extreme pressures, which could lead to higher response to screening invitations

Amsterdam, March 1, 2017 – Sigmascreening, a Dutch medical device company focusing on the development of new innovative products in the area of digital mammography and breast cancer screening, will demonstrate its groundbreaking Sensitive Sigma™ Paddle at the upcoming European Radiology Congress (ECR) in Vienna, 1 – 5 March, EXPO Hall X1 – booth no. 22. The paddle is the first pressure based compression paddle in the market providing real-time and reproducible mammographic pressure information and will considerably reduce commonly experienced unnecessary pain for women during screening. This could lead to higher response to screening invitations.

Ivo Aarninkhof, CEO of Sigmascreening, is happy to welcome you in Sigma’s booth. He is proud of the benefits that the Sensitive Sigma™ Paddle brings to women and their health:

“Measuring and visualizing a – previously not available – parameter, pressure, which allows breast screening centres and hospitals to take breast size and tissue stiffness into account. This avoids current negative consequences by under- or over compression of the breast and enables a highly reproducible procedure, year after year.”

But apart from patients, also radiographers and radiologists benefit from pressure based compression. The real-time visualization of the applied pressure gives more insights in what to expect, which leads to a faster more pleasant and much more accurate procedure.

Pressure-standardized breast compression is expanding rapidly in screening centres and hospitals throughout Europe. In Europe, over 10,000 patients already experienced the more woman-friendly way of making mammograms. The Sensitive Sigma™ Paddle with CE marking is already being used in the United Kingdom, Germany, Sweden, The Netherlands, Belgium and Switzerland.

About Sigmascreening

Sigmascreening, an Amsterdam based medical device company focusing on the development of new innovative products in the area of digital mammography and breast cancer screening. Sigmascreening was established as a spin-off company from the Academic Medical Center Amsterdam (AMC Amsterdam).

Sigmascreening has several products under development. The Sensitive Sigma™ Paddle is the first product with CE marking, based on patented technology. It optimizes compression for every single breast and takes breast size and stiffness into account, preventing unnecessary discomfort or pain. A highly reproducible procedure with the same physical experience, year after year. Sigmascreening aims to introduce new products that will improve mammography and contribute to the early detection of cancer which ultimately can save lives.

For more information please contact:

Sigmascreening, Amsterdam - Ivo Aarninkhof
Tel: +31 6 12 04 17 14 | E-mail:

LifeSpring LifeSciences Communication, Amsterdam - Leon Melens
Tel: +31 6 538 16 427 | E-mail:

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Publications in peer-reviewed journals

2017 - Influence of breast compression pressure on the performance of population-based mammography screening
In a retrospective study of 57,179 women participating in the Dutch population based screening program with a total of 132,776 digital mammographic examinations, digital image analysis was used to determine the pressure exercised during image acquisition. Volpara software was used for the analysis. The data were subdivided into quintiles of pressure and the number of screen-detected cancers, interval cancers, false positives, and true negatives were determined for each of the 5 groups. Generalized estimating equations (GEE) were used to account for confounders; pair-wise testing for significant differences was performed. In conclusion; results suggest that if too much pressure is applied during mammography this may reduce sensitivity. In contrast, if pressure is low this may decrease specificity.  A similar study on data of the Norwegian population based screening was recently published by N. Moshina et al in Breast Cancer Res Tr  (2017 Jun;163(3):605-613),  with comparable results. 
2017 - Mammographic compression at Asian women
This study showed that a force-standardized mammographic compression practice led to widely variable compression parameters in Asian women. Asian women, who generally have smaller breasts, are subject to force standardized protocols. These protocols have largely been optimized for Caucasian women and might not be suitable for them. The mean ± standard deviation compression pressure for all mammograms (n = 15818) was 17.77±10.51 kPa. A phantom study showed that reducing compression force in Asian women has a limited impact on image quality and mean glandular dose.