Slider 8 Publications
A breakthrough innovation in mammography based on extensive scientific research.
Slider 6 Publications
Highly reproducible breast compression, year after year.
Slider 3 Publications
Reproducible mammogram with similar image quality while avoiding extreme pressures.

News, publications and more related articles

Publications in peer-reviewed journals News PhD Thesis Media Articles
2017 - Mammographic compression in Asian women
This study showed that a force-standardized mammographic compression practice led to widely variable compression parameters in Asian women. Asian women, who generally have smaller breasts, are subject to force standardized protocols. These protocols have largely been optimized for Caucasian women and might not be suitable for them. The mean ± standard deviation compression pressure for all mammograms (n = 15818) was 17.77±10.51 kPa. A phantom study showed that reducing compression force in Asian women has a limited impact on image quality and mean glandular dose.
2017 - Is breast compression associated with breast cancer detection and other early performance measures in a population-based breast cancer screening program?
To investigate early performance measures in a population-based breast cancer screening program, this study extracted compression force information and calculated pressure from DICOM-images on 261,641 mammographic examinations from 93,444 subsequently screened women. Results indicate that high compression force and low compression pressure provided more favorable performance measures, compared with low compression force and high compression pressure.
Press release - Groundbreaking pressure based mammographic paddle at European Radiology Congress (ECR), Vienna
Amsterdam, March 1, 2017 – Sigmascreening, a Dutch medical device company focusing on the development of new innovative products in the area of digital mammography and breast cancer screening, will demonstrate its groundbreaking Sensitive Sigma Paddle at the upcoming European Radiology Congress (ECR) in Vienna, 1 – 5 March, EXPO Hall X1 – booth no. 22. The paddle is the first pressure based compression paddle in the market providing real-time and reproducible mammographic pressure information and will considerably reduce commonly experienced unnecessary pain for women during screening. This could lead to higher response to screening invitations.
2017 - Compression force and radiation dose in the Norwegian Breast Cancer Screening Program
In this analysis of 17951 screening mammograms from 14 breast centers in the Norwegian Breast Cancer Screening Program a wide variation in mean compression forces between and within the different breast centers was observed. The maximum difference in mean compression force between the centers was 63N for CC-view and 57N for MLO-view. There was a low correlation between compression force and radiation dose, possibly due to breast characteristics and differences in choice of exposure parameters between vendors.
2017 - Pressure-standardised mammography does not affect visibility, contrast and sharpness of stable lesions.
Four experienced radiologists scored visibility, contrast and sharpness for 188 stable lesions and structures that were visible in pairs of mammograms: those obtained with a pain-tolerance limited 18 decanewton target force compression protocol and those obtained with the Sigmascreening 10 kPa (75 mmHg) pressure-standardized compression protocol. The latter compressions were significantly milder but nonetheless the lesion visibility, contrast and sharpness were statistically not inferior.
2017 - Is Individualizing Breast Compression during Mammography useful?
Investigations of pain indications during mammography relating to compression force and surface area of the compressed breast. Fortschr Röntgenstr 2017; 189(01): 39-48.
Annual Symposium Breast Screening Belgium. February 4, 2017, Bruges, Belgium
During the annual symposium Breast Cancer Screening in Belgium Sigmascreening will give a presentation on pressure-based breast compression. In this lecture we go deeper into the question whether optimal compression leads to better image quality which leads to an improved detection of breast cancer?
2016-11-29 - Dutch companies praised for their technological prowess and contributions to medical imaging
An article by AuntMinnie about the Dutch contribution to the RSNA 2016 in the South Building of McCormick Place in Chicago. During a special session on Monday, companies from the Netherlands, where under Sigmascreening, were praised for their technological prowess and contributions to medical imaging.
2016-11-28 - USA Chicago - Target Pressure could Improve Breast Detection Rates
Sensitive Sigma Paddle from Sigmascreening, with Intermediate Target Pressure, Could Improve Breast Detection Rates Based on Research Presented at RSNA. The impact of pressure in breast compression on screening performance was the focus of research accepted for presentation here at the 102nd Annual Radiological Society of North America (RSNA) meeting, November 27-December 2, 2016. It appears that Sigmascreening’s Sensitive Sigma Paddle, with its intermediate target pressure, could also improve detection rates.
2016-11-23 Presentation: High Breast Compression in Mammography May Reduce Sensitivity
Presentation: High Breast Compression in Mammography May Reduce Sensitivity by Nico Karssemeijer, PhD, Nijmegen, Netherlands at the RSNA on Monday, Nov. 28 10:10AM - 10:20AM Room: Arie Crown Theater, RC215-08.
2016-11-22 - Sigmascreening to Introduce Sensitive Sigma Paddle at RSNA 2016
Sigmascreening will introduce the Sensitive Sigma Paddle at the upcoming 102nd Annual Radiological Society of North America (RSNA) meeting, Nov. 27-Dec. 2 in Chicago. The Sensitive Sigma Paddle enables personalized compression for better quality mammograms without unnecessary discomfort for patients.
2016-11-14 - Sigmascreening to debut breast paddle at RSNA 2016
By Auntminnie – Sigmascreening will use the upcoming RSNA 2016 meeting to introduce Sensitive Sigma Paddle, which enables personalized compression for mammograms. The Sensitive Sigma Paddle makes it possible to incorporate additional parameters in the process of breast compression during mammography, such as breast size and tissue stiffness during positioning. The paddle has multiple sensors that measure each breast to optimize compression for each breast. Based on breast size and tissue stiffness, the Sensitive Sigma Paddle calculates the pressure to achieve an optimal compression of 75 mm Hg and allows for a highly reproducible procedure.
2016 Oct - Pressure controlled compression of the breast in mammography
Recent results show that the performance of mammography, in terms of detect- ability of cancerous lesions can be affected by the compression pressure at which the examination is carried out. This article describes the rationale behind the development of a pressure-based compression system. (First published in DIEurope October 2016)
2016 - Performance of Breast Cancer Screening Depends on Mammographic Compression
Breast Cancer detection and Positive Predictive value (PPV) are 20-30% significantly better with the highest PPV at compression pressures between 9.18 kPa, and 10.7 kPa; this correspondents to approximately with 75 mmHg. These results strongly support the hypothesis that there is an optimal pressure during breast compression...
2016-01-27 - Joint project of SigmaScreening and ScreenPoint Medical receives subsidy from European Fund for Regional Development
Mechanical breast parameters that can be obtained with the Sensitive Sigma Paddel may improve the sensitivity of Computer Aided Diagnosis developed by ScreenPoint Medical.
2016-02-05 - Trouw (national Dutch paper)
Het röntgenonderzoek naar borstkanker doet vaak pijn. De borsten worden met soms twintig kilo kracht tussen twee platen platgedrukt. Eindelijk is er een nieuwe techniek.
2015-12-26 - De Morgen (Flemish newspaper)
Nieuwe techniek maakt borstonderzoek minder pijnlijk. Speciale aandrukplaat 'personaliseert' druk op de borsten bij het maken van röntgenfoto's.
2015-12-24 - Volkskrant (national Dutch paper)
Met een nieuwe techniek is het niet meer nodig borsten te pletten om een mammografie te kunnen maken.
2015-10-08 - De Ingenieur (Dutch magazine)
Voor veel vrouwen is de screening op borstkanker een martelgang. De test gebeurt met een mammograaf, een soort persmachine.
2015-08-18 - GE Healthcare magazine
Drukgestuurde borstaandrukking op de GE Senographe™ Essential: betere kwaliteit en minder onnodige pijn.
2015-06-18 - Margriet (Dutch magazine)
Geen vrouw die er niet als een berg tegenop ziet: de mammografie. Sinds kort heeft het AMC een methode die vooral bij vrouwen met kleine borsten minder pijn doet.
2015-05-11 - MTintegraal
Gepersonaliseerde borstsamendrukking tijdens mammografie.
2012-04-21 - Financieel Dagblad (Dutch Financial Times)
Een nieuwe test op borstkanker kan het einde inluiden van de gangbare methode die voor miljoenen vrouwen met veel pijn gepaard gaat.
2010-12-21 - Volkskrant (national Dutch paper)
Voor veel vrouwen is de screening op borstkanker een pijnlijke aangelegenheid. Onnodig, blijkt nu.
2010-10-06 - Sigmascreening closes financing round
Het Life Sciences FundAmsterdam, dat in 2009 van start is gegaan om biomedische bedrijven binnen de regio groot-Amsterdam te financieren, heeft de financiering verstrekt en is toegetreden als aandeelhouder tot
Sigmascreening.
2016 - Force balancing in mammographic compression
Skin stretching is often regarded as an inevitable side-effect of mammographic breast compression, but this study shows that much unnecessary stretching can be avoided by adequately adjusting the position of the X-ray image receptor to the height of the patient...
2015-11-06 - CE marking for Sensitive Sigma Paddle
SigmaScreening B.V. earned an important certification for the EU this week and wants to quickly make this innovation available to as many women as possible.
2015-06-19 - Participation fund invests in SigmaScreening
SigmaScreening B.V. has successfully concluded its financing round after signing a strategic collaboration with the Participation Fund of De Friesland Insurance (DFZ)...
2015-03-02 - Press release of EJR paper
One of our latest papers, "Mammographic compression - A need for mechanical standardization", was featured in a...
2014-11-30 - Presentation at RSNA 2014 Annual Meeting
Dr. Woutjan Branderhorst has presented the results of our validation study at the RSNA 2014 Annual Meeting. This study was also selected for a...
2014-11-26 - Sigma Paddle explained on Canadian television
An independent expert, professor Martin J. Yaffe from the University of Toronto, comments on the Sigma Paddle in CTV News Toronto.
2014-11-25 - Interview about Sigma Paddle
Today a nice interview was published on TODAY Health about the validation study to be presented at the RSNA 2014 Annual Meeting.
2014-06-26 - SigmaScreening winner of MedTech Innovation Award
Sigmascreening was chosen today as the best medical technological innovation of this year. Out of 24 submissions, this invention was expected to be the best capable of improving the current medical practice, and moreover of yielding a favourable cost/benefit ratio for patient, doctor, hospital and health care insurers.
2015 - Mammographic compression - A need for mechanical standardization
This report reveals how large the variation in applied force and pressure is in current daily practice, and concludes that calculating and tracking compression pressure could help to standardize quality and patient experience in mammography...
2014-03-07 - SigmaScreening closes financing round and signs strategic collaboration
SigmaScreening B.V. has successfully concluded its financing round after signing a strategic collaboration with an investor syndicate...
2015 - Towards personalized compression in mammography: A comparison study between pressure- and force-standardization
This validation study describes our first experience with pressure standardization, showing that its implementation is feasible, and that it can reduce pain without affecting radiation dose or image quality.
2014 - Mammographic compression after breast conserving therapy: Controlling pressure instead of force
This study shows that especially patients treated with breast conserving therapy benefit from a pressure-controlled compression protocol. 
2013 - A novel approach to mammographic breast compression: improved standardization and reduced discomfort by controlling pressure instead of force
To show that a pressure-controlled compression protocol improves standardization and reduces discomfort and pain, with limited effects on image quality and radiation dose.
2013 - Pressure and breast thickness in mammography: what about physics?
Pressure and breast thickness in mammography: what about physics?
More articles